MOTS-C Research Profile
Laboratory-focused reference connecting the current catalog record for MOTS-C with analytical context, public batch evidence and related research documentation.
Current catalog abstract
Documented material overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome and recognized for its role in regulating cellular metabolism and energy homeostasis. It functions as a signaling molecule that can translocate to the nucleus under metabolic stress and influence the expression of genes involved in metabolic adaptation. In research settings, MOTS-c has been shown to activate pathways associated with AMP-activated protein kinase (AMPK), contributing to enhanced glucose utilization, improved insulin sensitivity, and regulation of lipid metabolism. Additionally, it has been studied for its role in promoting mitochondrial function, cellular stress resistance, and metabolic flexibility, particularly in skeletal muscle and other energy-demanding tissues. Due to its involvement in key metabolic signaling networks, MOTS-c is of significant interest in studies related to aging, metabolic disorders, and cellular resilience. This compound is intended strictly for research purposes only and is not for human consumption, clinical use, or therapeutic application.
Evidence chain
Published batch documentation
Related research
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