KPV 10 mg Research Profile

Current catalog abstract

Documented material overview

KPV (Lysine–Proline–Valine) is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), known for its role in modulating inflammatory and immune responses. Unlike the full α-MSH peptide, KPV retains potent anti-inflammatory activity while lacking significant melanogenic effects, making it a subject of interest in targeted research applications. Mechanistically, KPV has been shown to influence pro-inflammatory cytokine pathways, including the inhibition of nuclear factor kappa B (NF-κB) signaling, thereby reducing the expression of inflammatory mediators such as TNF-α and interleukins. In experimental models, it has been studied for its effects on immune modulation, gastrointestinal inflammation, and tissue repair processes. Due to its small size and stability, KPV demonstrates favorable characteristics for investigating localized and systemic inflammatory responses. This compound is intended strictly for research purposes only and is not for human consumption, clinical use, or therapeutic application.